Cardiac Sarcoidosis Diagnostic Probability Score (HRS adaptation)

Cardiac Sarcoidosis Diagnostic Probability Score (HRS adaptation): Explanation and Clinical Context This calculator operationalizes the 2014 Heart Rhythm Society (HRS) consensus statement on cardiac sarcoidosis. A definitive diagnosis requires myocardial biopsy showing non-caseating granulomas, whereas a probable diagnosis requires histologically proven extracardiac sarcoidosis plus one or more typical cardiac features and exclusion of other causes. Typical cardiac features include high-grade AV block, sustained VT, unexplained reduced LVEF, characteristic FDG-PET uptake, CMR with LGE, perfusion defect compatible with CS, or steroid-responsive cardiomyopathy.

The exploratory probability index is a heuristic, non-validated scoring framework designed to approximate diagnostic confidence, not to replace the categorical HRS definitions.