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Interactive worksheet
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Clinical contextWhy this tool matters and how to interpret it
Understand the result,
not just the number.
Global Longitudinal Strain Early Change Index (GLS-ECI): Explanation and Clinical Context The Global Longitudinal Strain Early Change Index (GLS-ECI) is a sensitive echocardiographic measure used to detect early myocardial dysfunction before overt changes in left ventricular ejection fraction occur. It is calculated as the percentage change between baseline GLS and follow-up GLS: GLS-ECI (%) = (Follow-up GLS − Baseline GLS) / |Baseline GLS| × 100. A higher negative change (larger absolute reduction in GLS) indicates early subclinical myocardial injury, commonly used in patients undergoing cardiotoxic chemotherapy or at risk of heart failure.
GLS-ECI allows clinicians to detect myocardial dysfunction early and implement cardioprotective strategies promptly.
Evidence & references1 primary source mapped
- Source 1
Thavendiranathan P, et al. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer therapy. J Am Coll Cardiol. 2014;63(25 Pt A):2751-2768. doi:10.1016/j.jacc.2014.01.073
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