Heart Failure Polygenic Risk Score (HF-PRS) Calculator

Heart Failure Polygenic Risk Score (HF-PRS): Explanation and Clinical Context The Heart Failure Polygenic Risk Score (HF-PRS) quantifies an individual's genetic predisposition to heart failure by summing the weighted effects of multiple single nucleotide polymorphisms (SNPs) previously associated with the disease. It is calculated as the sum of the number of risk alleles for each SNP multiplied by its corresponding effect size (log odds ratio) derived from large-scale genome-wide association studies (GWAS). Higher HF-PRS values indicate greater inherited susceptibility to developing heart failure, independent of traditional risk factors.

Clinically, HF-PRS can support risk stratification, early preventive strategies, and personalized management in patients with borderline or ambiguous risk profiles.