PARADIGM-HF Responder Index (AWARD-Class) Calculator

AWARD-Class / PARADIGM-HF Responder context and interpretation The AWARD-Class score (derived from a two-center real-world cohort) is an easy-to-calculate index intended to predict a 1-year “super-response” to sacubitril/valsartan, defined in the derivation study as absence of HF admission/transplant/death plus either ≥50% NT-proBNP reduction and/or ≥10-point increase in LVEF. The score uses six routinely available clinical variables (MRA use, sex, recent HF admission, ECG rhythm, diuretics use, and NYHA class) and maps the summed points to three probability groups (low, intermediate, high). Use this tool as an adjunct to clinical judgment — it was derived from an observational cohort and has not replaced randomized evidence.