Interactive worksheet
Interactive worksheet
Clinical inputs
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Clinical contextWhy this tool matters and how to interpret it
Understand the result,
not just the number.
Pulmonary Vasoreactivity Test Response Prediction Model: Explanation and Clinical Context This tool integrates a heuristic pre-test probability of a positive acute vasoreactivity test (AVT) response with established adult response criteria (Sitbon and Barst). Classic AVT response is defined by a ≥10 mmHg fall in mPAP to ≤40 mmHg without a drop in cardiac output (Sitbon), or ≥20% decrease in both mPAP and PVR with unchanged or increased CO (Barst/Rich). The pre-test estimation favors idiopathic/heritable PAH, younger age, lower baseline mPAP and RAP, higher CO, lower PVR, and lower NT-proBNP or RDW.
Use this tool to aid decision-making and counselling; not as a substitute for guideline-based evaluation. References Chin KM, et al. Eur Respir J.
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2015. Tonelli AR, et al. Respir Med.
2010;104(4):593–600. Xi Q, et al. Clin Chim Acta.
2015;447:95–98. Tea I, et al. Methodist DeBakey Cardiovasc J.
2021;17(4):64–74.
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