Systemic Inflammation Response Index (SIRI) Calculator

Systemic Inflammation Response Index (SIRI): Explanation and Clinical Context SIRI is a novel biomarker that quantifies systemic inflammation by integrating neutrophil, monocyte, and lymphocyte counts. It is calculated as (Neutrophil count × Monocyte count) / Lymphocyte count. This index has been studied for prognostic value in cardiovascular diseases, oncology, and sepsis.

A higher SIRI reflects a greater inflammatory state, which is associated with worse clinical outcomes. SIRI is particularly useful for risk stratification, guiding treatment intensity, and monitoring response to anti-inflammatory therapies.