LV GLS Drop >15% Calculator
LV GLS Drop >15% Rule: Explanation and Clinical Context The LV GLS (Left Ventricular Global Longitudinal Strain) Drop >15% Rule is used for early detection of subclinical cardiotoxicity, particularly in patients receiving potentially cardiotoxic chemotherapy, such as anthracyclines or trastuzumab. GLS is a sensitive echocardiographic parameter reflecting myocardial deformation. A relative reduction of more than 15% f