1,329 calculators and references across 60 specialties, with formula confidence shown up front.
DANISH Trial — ICD Subgroup Mortality Index: Explanation and Clinical Context This tool is an educational, exploratory calculator that maps an individual patient’s profile onto the principal subgroup findings from the DANISH randomized trial (Køber et al., NEJM 2016) and subsequent subgroup/extended analyses. The DANISH trial randomized 1,116 patients with non-ischemic systolic heart failure to receive an ICD or usua
DAPA-HF Response Predictor: Explanation and Clinical Context The DAPA‑HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) trial demonstrated that dapagliflozin significantly reduced the risk of cardiovascular death or worsening heart failure in patients with heart failure and reduced ejection fraction (HFrEF). In subsequent analyses, investigators explored baseline variables to identify which patie
DAPT-CHF Subgroup Analysis Index: Explanation and Clinical Context The DAPT-CHF Subgroup Analysis Index estimates the net clinical benefit of prolonged dual antiplatelet therapy (DAPT) in patients with coronary stents who have coexisting chronic heart failure (CHF). The original DAPT Study demonstrated that extended DAPT beyond 12 months reduced stent thrombosis and myocardial infarction but increased moderate or sev
DECLARE–TIMI 58 HF Risk Reduction Score: Explanation and Clinical Context The DECLARE–TIMI 58 trial evaluated over 17,000 patients with type 2 diabetes, with or without established atherosclerotic cardiovascular disease, assessing dapagliflozin versus placebo for major adverse cardiovascular and heart failure outcomes. The study demonstrated a significant reduction in hospitalization for heart failure, irrespective o
: Explanation and Clinical Context The calculator estimates the 2-year absolute benefit of adding dapagliflozin 10 mg once daily in patients with symptomatic heart failure with left ventricular ejection fraction (LVEF) > 40% (mildly reduced or preserved). The estimate uses a simplified model based on the primary endpoint of the DELIVER trial (composite of cardiovascular death or worsening heart failure) in which dapa
DETECT ICD algorithm — explanation and clinical context The DETECT ICD tool is a pragmatic, rule-based decision support algorithm to help clinicians triage patients with syncope who may require consideration of implantable cardioverter-defibrillator (ICD) therapy or expedited electrophysiology evaluation. It prioritizes: (1) clear secondary-prevention indications such as documented sustained ventricular tachycardia (
DETERMINE-AHF Composite Outcome Algorithm — Explanation and Clinical Context This page implements a prototype calculator designed to estimate the probability of a pre-specified composite adverse outcome in acute heart failure (AHF) using a logistic regression style formula. The prototype accepts common, admission-time clinical variables (age, systolic blood pressure, heart rate, creatinine, BUN, NT-proBNP, LVEF, and