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AF Polygenic Risk Score (AF-PRS) Calculator

AF Polygenic Risk Score (AF-PRS): Explanation and Clinical Context The AF Polygenic Risk Score (AF-PRS) quantifies an individual's inherited genetic susceptibility to atrial fibrillation based on the cumulative effect of multiple risk alleles. It is derived from genome-wide association studies (GWAS) that identify common single nucleotide polymorphisms (SNPs) associated with AF risk. The PRS is calculated by summing

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APOE Genotype Risk Index Calculator

APOE Genotype Risk Index (E2/E3/E4 variants): Explanation and Clinical Context The Apolipoprotein E (APOE) gene has three major alleles: E2, E3, and E4. The combination of these alleles determines an individual's genotype, which significantly influences lifetime risk for Alzheimer's disease and cardiovascular outcomes. E2 allele is generally protective, E3 is neutral, and E4 increases risk, particularly in homozygous