Interactive worksheet
KCNQ1 KCNH2 Mutation Severity Classifier
KCNQ1 / KCNH2 Mutation Severity Classifier: background and clinical context This classifier synthesizes information about variant type (truncating vs missense vs CNV), protein location (pore, voltage sensor, transmembrane, regulatory domains), predicted functional effect (loss-of-function, dominant-negative, gain-of-function), and clinical phenotype (QTc duration, syncope, cardiac arrest, family sudden cardiac death)