Interactive worksheet
TTN Truncating Variant Risk Stratifier
: Rationale, Interpretation & Clinical Context Truncating variants in the TTN gene (TTNtv) are among the most common genetic contributors to dilated cardiomyopathy (DCM) and have been associated with increased risk of heart failure, atrial fibrillation, and adverse cardiac events in multiple cohort studies. Risk modifiers identified across the literature include whether the TTNtv lies in exons with high proportion sp