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Immune Checkpoint Inhibitor Myocarditis Risk Index Calculator

Immune Checkpoint Inhibitor Myocarditis Risk Index: Explanation and Clinical Context This risk index is derived from a multicenter study involving 748 patients treated with immune checkpoint inhibitors (ICIs). The index incorporates five key factors: presence of active thymoma, cardio-muscular symptoms, low QRS voltage on electrocardiogram, left ventricular ejection fraction (LVEF) <50%, and elevated troponin levels.

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Immune Checkpoint Inhibitor Myocarditis Risk Index: Explanation and Clinical Context This risk index is derived from a multicenter study involving 748 patients treated with immune checkpoint inhibitors (ICIs). The index incorporates five key factors: presence of active thymoma, cardio-muscular symptoms, low QRS voltage on electrocardiogram, left ventricular ejection fraction (LVEF) <50%, and elevated troponin levels. A higher score correlates with an increased risk of severe myocarditis and related adverse cardiac events.

Clinicians can use this tool to stratify patients and tailor management strategies accordingly.

Evidence & references1 primary source mapped
  1. Source 1

    Power JR, Dolladille C, Ozbay B, et al. Immune checkpoint inhibitor-associated myocarditis: a novel risk score. Eur Heart J. 2025;ehaf315. doi:10.1093/eurheartj/ehaf315.

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Active local worksheet: mapped inputs can be completed, validated, copied, saved, and exported on this device. No numerical score is asserted unless its formula is independently reproducible.

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Clinical structure and calculation context point directly to Source 1; additional primary references remain listed for auditability.