Maternal Biomarker Index (BNP-based) Calculator

Maternal Biomarker Index (BNP-based): Explanation and Clinical Context The Maternal Biomarker Index (MBI) is a predictive tool developed to assess the risk of maternal complications during pregnancy, particularly in women with underlying cardiac stress. The index integrates B-type Natriuretic Peptide (BNP) levels, maternal age, and gestational week to provide a composite score that correlates with the likelihood of adverse maternal outcomes. BNP is a cardiac biomarker reflecting ventricular stress and fluid overload, which can signal subclinical heart failure or hemodynamic strain in pregnant women.

Age and gestational week further refine risk estimation, as older maternal age and late gestation can increase susceptibility to complications. The resulting MBI score is stratified into low, moderate, and high-risk categories, aiding clinicians in early identification, monitoring, and intervention planning.