THEMIS-PCI Benefit vs Bleeding Algorithm
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1,329 calculators and references across 60 specialties, with formula confidence shown up front.
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TRACE Study — Post-MI Heart Failure Risk (explanation and clinical context) This calculator is TRACE-inspired: the original TRAndolapril Cardiac Evaluation (TRACE) was a randomized trial that enrolled patients with reduced left ventricular function soon after myocardial infarction and demonstrated morbidity and mortality benefits of long-term ACE inhibition (trandolapril) in that population. TRACE showed that LV syst
: Explanation and Clinical Context The TRANSFORM-HF Mortality Comparison Index is derived from the TRANSFORM-HF trial (Felker GM, et al., NEJM 2022), which compared torsemide and furosemide in patients hospitalized with heart failure. The trial demonstrated no statistically significant difference in all-cause mortality at 12 months between the two diuretics (26.1% vs 26.2%; HR 1.02, 95% CI 0.89–1.18). This calculator
TRED-HF Recovery / Relapse Prediction — explanation and clinical context The TRED-HF randomized pilot trial examined phased withdrawal of all heart failure pharmacotherapy in carefully selected patients with previously dilated cardiomyopathy who had asymptomatic recovery of left ventricular function (LVEF ≥50%), normalised indexed LV volumes, and low NT-proBNP at baseline; approximately 40–44% of participants relapse
TRUE-AHF Prognostic Classification — explanation and clinical context This page implements an experimental prognostic classifier inspired by common predictors used in acute heart failure (AHF) prognostic models: advanced age, low systolic blood pressure, tachycardia, elevated BUN/creatinine, hyponatremia, elevated natriuretic peptides (NT-proBNP), reduced left ventricular ejection fraction, and positive cardiac tropo
Exploratory : Explanation and context The TWILIGHT randomized trial tested whether, among high-risk patients who had completed 3 months of dual antiplatelet therapy after PCI, stopping aspirin and continuing ticagrelor monotherapy reduced clinically relevant bleeding without increasing ischemic events. The trial found a lower rate of BARC 2/3/5 bleeding with ticagrelor monotherapy versus ticagrelor plus aspirin, with