ARVC Screening Probability in Athletes (Family History + ECG) Calculator

ARVC Screening Probability in Athletes: Explanation and Clinical Context This calculator assists sports cardiologists in assessing pre-test probability for arrhythmogenic cardiomyopathy (ARVC/ACM) in athletes using key signals: family history and characteristic ECG abnormalities. A first-degree relative with confirmed ARVC or a pathogenic variant markedly raises pre-test suspicion. Similarly, young-age sudden cardiac death in the family warrants caution.

On ECG, T-wave inversion beyond V2 in athletes aged ≥16 years, inferolateral T-wave inversion, a terminal activation duration ≥55 ms in V1–V3, or epsilon waves are red flags for pathological remodeling. Athletes categorized “High” should undergo cardiac imaging (echo, CMR), Holter or exercise ECG, and potentially genetic testing before sports clearance. This tool is not for diagnostic use but to prioritize further evaluation.