Coronary Artery Calcium (CAC) Percentile Ranking Calculator

Coronary Artery Calcium (CAC) Percentile Ranking: Explanation and Clinical Context CAC percentile ranking provides an age- and sex-specific comparison of an individual's coronary artery calcium score to a reference population, as defined in the Multi-Ethnic Study of Atherosclerosis (MESA). It helps to stratify atherosclerotic cardiovascular disease (ASCVD) risk beyond traditional risk factors. A higher percentile indicates a higher burden of coronary calcification relative to peers, suggesting elevated risk of future coronary events.

For example, a CAC score of 0 generally corresponds to very low risk (<25th percentile), whereas a CAC score above the 75th percentile indicates substantially higher risk. Clinicians can use CAC percentiles to guide preventive strategies such as statin therapy, lifestyle modifications, and monitoring intensity.