COMPERA 2.0 Risk Model Calculator

COMPERA 2.0 Risk Model: Explanation and Clinical Context The COMPERA 2.0 Risk Model is an updated four-strata prognostic system for patients with pulmonary arterial hypertension (PAH), derived from the large COMPERA registry. It refines the previous three-strata model by dividing the intermediate group into two categories: intermediate-low and intermediate-high, enhancing clinical decision-making and treatment targeting. This model integrates six routinely available clinical, functional, and hemodynamic parameters — WHO functional class, 6-minute walk distance (6MWD), NT-proBNP, right atrial area, right atrial pressure, and cardiac index — to generate a composite mean score ranging from 1 (low risk) to 4 (high risk).

Each parameter contributes equally to the overall score. The calculated mean score corresponds to one of four risk categories associated with distinct 1-year mortality rates: low (<2%), intermediate-low (2–7%), intermediate-high (7–20%), and high (>20%). Clinically, this tool helps physicians assess baseline severity and monitor therapeutic response during follow-up.

Patients in the low or intermediate-low risk categories are generally considered stable or improving, while those in intermediate-high or high risk require intensified or advanced therapy such as combination regimens or parenteral prostacyclin, and in selected cases, lung transplantation evaluation.