Interactive worksheet
Interactive worksheet
Clinical inputs
0/12 filled
Clinical contextWhy this tool matters and how to interpret it
Understand the result,
not just the number.
Endothelial Dysfunction Post-COVID Index (Explanation and Clinical Context) This calculator combines validated indices of endothelial stress and an exploratory composite to contextualize post-COVID vascular dysfunction. EASIX = LDH × Creatinine / Platelets — initially validated in hematologic and COVID-19 populations. Higher EASIX correlates with worse endothelial activation and outcomes.
Age-adjusted EASIX (aEASIX-COVID) = EASIX × Age, proposed to improve risk stratification in SARS-CoV-2 infection. Exploratory Biomarker Composite integrates endothelial activation markers (VWF:Ag, sP-selectin, sTM, ICAM-1, VCAM-1, D-dimer, Endothelin-1, Syndecan-1) normalized to reference limits, reflecting systemic endothelial stress. Clinical Use: Interpret trends in context with imaging, inflammatory, and functional tests.
Not diagnostic; for research and clinical insight only.
Evidence & references7 primary sources mapped
- Source 1
Luft T, et al. Blood.
- Source 2
Pérez-García F, et al. J Clin Med.
- Source 3
Kalicińska E, et al. Sci Rep.
- Source 4
Osburn WO, et al. Front Immunol.
- Source 5
Tsiatsiou P, et al. Thromb Res.
- Source 6
Ambrosino P, et al. Atherosclerosis.
- Source 7
Xu S, et al. Cardiovasc Res. 2023.
Clinical discussionModerated, tool-specific conversation
Loading discussion…