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Interactive worksheet
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Clinical contextWhy this tool matters and how to interpret it
Understand the result,
not just the number.
Post-COVID Thrombotic Risk Composite (D-dimer + Clinical): Explanation and Clinical Context This calculator applies the IMPROVE-DD model, combining clinical factors with D-dimer elevation (≥2× ULN) to estimate venous thromboembolism (VTE) risk in post-COVID patients. Clinical Significance: High scores identify patients who may benefit from extended prophylaxis with rivaroxaban 10 mg daily for 35 days post-discharge (as shown in the MICHELLE trial). Low scores suggest no prophylaxis is needed.
Interpretation: 0–1 = Low risk 2–3 = Moderate risk ≥4 = High risk
Evidence & references1 primary source mapped
- Source 1
Gibson CM, Spyropoulos AC, Cohen AT, et al. TH Open. 2017;1:e56–e65. Giannis D, Barish MA, Goldin M, et al. Blood. 2021;137:2838–2847. Ramacciotti E, Agati LB, Calderaro D, et al. Lancet. 2022;399:50–59. Spyropoulos AC, et al. Res Pract Thromb Haemost. 2021;5:e12596. Stoneham SM, et al. Br J Haematol. 2020;190:e76–e78.
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