HF-ACTION Risk Calculator

Age (years) Sex (0 = female, 1 = male) Left Ventricular Ejection Fraction (LVEF %) NYHA Functional Class (II=2, III=3, IV=4) Baseline Exercise Duration (minutes) Baseline Kansas City Cardiomyopathy Questionnaire (KCCQ) Symptom Stability Score (0-100) Serum Blood Urea Nitrogen (BUN) – mg/dL HF-ACTION Predictive Risk Score Model: Explanation and Clinical Context The HF-ACTION Predictive Risk Score Model was derived from the HF-ACTION trial, which enrolled ambulatory patients with chronic heart failure due to systolic dysfunction (NYHA class II-IV, LVEF <35%) and followed them for a median of 2.5 years. The model identifies key baseline predictors of the composite of all‐cause death or hospitalization, and of all‐cause death alone. Among the strongest predictors were baseline exercise duration on cardiopulmonary exercise testing, KCCQ symptom stability score, elevated BUN, and male sex.

Clinically, this tool supports risk stratification by identifying higher‐risk patients who may benefit from intensification of therapy (e.g., advanced device therapy, closer monitoring, structured exercise training) and lower‐risk patients for whom routine interventions may be sufficient.