MADIT-CRT Responder Score Calculator

MADIT-CRT Responder Score: Explanation and Clinical Context The MADIT-CRT Responder Score was developed from the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) to identify heart failure patients most likely to experience reverse left ventricular remodeling and clinical benefit from CRT. This score integrates key predictors including female sex, non-ischemic etiology, presence of LBBB morphology, longer QRS duration (≥150 ms), higher baseline LV volumes, and less advanced NYHA functional class. Patients with these features have a substantially higher probability of favorable LV remodeling and improved survival.

In the original analysis, female sex and LBBB morphology were the strongest independent predictors of CRT response. Patients with a score of ≥7 had approximately 80% probability of significant LV reverse remodeling, while those with a score ≤3 had less than 40% probability. This tool aids clinicians in patient selection for CRT, complementing guideline-based indications.

It is not a substitute for clinical judgment but provides a quantitative, evidence-based estimate derived from the MADIT-CRT population.