BIOSTAT-CHF Mortality Risk (Approximation) Calculator

BIOSTAT-CHF Mortality Risk: Explanation and Clinical Context The BIOSTAT-CHF (A systems BIOlogy Study to Tailored Treatment in Chronic Heart Failure) program developed and validated multivariable risk models for outcomes in heart failure using a large European cohort (index n≈2,516; validation n≈1,738). The five strongest independent predictors of all-cause mortality were: older age, higher blood urea nitrogen (BUN), higher NT-proBNP, lower haemoglobin, and lack of beta-blocker prescription. These variables are easily obtainable in clinical practice and provide strong prognostic discrimination.

This calculator implements a simplified educational approximation using those predictors. For accurate, validated probability estimates, the original Cox model coefficients and baseline hazard from the BIOSTAT-CHF publication and supplementary data must be applied.