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1,329 calculators and references across 60 specialties, with formula confidence shown up front.

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Adult Treatment Panel (ATP) Cardiometabolic Index Calculator

Adult Treatment Panel (ATP) Cardiometabolic Index: Explanation and Clinical Context The ATP Cardiometabolic Index (CMI) is a composite parameter derived from the ratio of triglycerides to HDL cholesterol, multiplied by waist circumference. It reflects the integrated risk of insulin resistance, visceral adiposity, and dyslipidemia—three core components of the metabolic syndrome defined by the National Cholesterol Educ

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Cushing’s Syndrome Cardiometabolic Risk Score Calculator

Cushing's Syndrome Cardiometabolic Risk Score: Explanation and Clinical Context The Cushing's Syndrome Cardiometabolic Risk Score is a tool designed to quantify the risk of metabolic and cardiovascular complications in patients with endogenous or exogenous hypercortisolism. The score incorporates common metabolic parameters including age, BMI, blood pressure, fasting glucose, triglycerides, and HDL cholesterol to str

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Diabetes-CVD Interaction Index Calculator

Diabetes-CVD Interaction Index: Explanation and Clinical Context This index is a proposed composite metric designed to reflect the synergistic effect of diabetes mellitus and cardiovascular disease (CVD) risk in patients. Key input variables include age, gender, duration of diabetes, glycaemic control (HbA1c), prior cardiovascular history and estimated glomerular filtration rate (eGFR). The underlying rationale is th

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Framingham Lipid Risk Subscore (10-Year CHD) Calculator

Framingham Lipid Risk Subscore: Explanation and Clinical Context The Framingham Lipid Risk Subscore estimates 10-year risk of coronary heart disease (CHD) using the lipid-based model, combining age, total cholesterol, HDL cholesterol, blood pressure, and smoking. It originates from the Framingham Heart Study and the Adult Treatment Panel III (ATP III) guidelines, which provide both point-based and regression-based ri

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HPEL (Hyperlipidemia) Predicted ASCVD Increment Calculator

Current LDL-C (mg/dL) Reference/Target LDL-C (mg/dL) (e.g., 70) HPEL (Hyperlipidemia) Predicted ASCVD Increment: Explanation and Clinical Context This tool estimates the incremental atherosclerotic cardiovascular disease (ASCVD) risk attributable to elevated LDL-C relative to a user-defined reference (commonly 70 mg/dL) by applying a log-linear relationship between LDL-C and major vascular events derived from large,

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Lipid Treatment Benefit Calculator (LDL Reduction Model)

: Explanation and Clinical Context This calculator estimates the expected benefit of lipid-lowering therapy using data derived from the Cholesterol Treatment Trialists’ (CTT) Collaboration. The model is based on large meta-analyses demonstrating that for each 1 mmol/L reduction in LDL-C, there is an approximate 22% relative reduction in major vascular events, including myocardial infarction, stroke, and cardiovascula

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Menopause-Associated ASCVD Risk Adjuster

: Explanation and Clinical Context This tool estimates a woman’s 10-year risk of atherosclerotic cardiovascular disease (ASCVD), incorporating traditional risk factors such as age, blood pressure, lipid profile, and smoking status, with an additional adjustment for age at menopause. Early menopause (before 55 years) is independently associated with increased ASCVD risk due to prolonged estrogen deficiency. The algori

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Metabolic Age Acceleration Index (CV Projection) Calculator

Metabolic Age Acceleration Index (CV Projection): Explanation and Clinical Context The Metabolic Age Acceleration Index (MAAI) is a composite measure designed to quantify cardiovascular risk in relation to metabolic aging. It integrates chronological age with clinical biomarkers including BMI, fasting glucose, systolic blood pressure, and total cholesterol, reflecting the biological acceleration of cardiovascular agi

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Metabolic Syndrome (ATP III) Score Composite

: Explanation and Clinical Context The ATP III definition operationalizes metabolic syndrome (MetS) as a cluster of five components—central obesity, elevated triglycerides, reduced HDL cholesterol, elevated blood pressure, and elevated fasting plasma glucose—of which any three confer a diagnosis. The original ATP III report (2001) used fasting plasma glucose ≥110 mg/dL; in 2005, an AHA/NHLBI scientific statement alig

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Metformin Benefit Prediction Model (Cardio-Protection) Calculator

Metformin Cardio-Protection: Explanation and Clinical Context This calculator estimates the potential absolute cardiovascular risk reduction when adding or continuing metformin, by applying an assumed relative risk reduction (RRR) to a patient’s baseline cardiovascular event risk over a specified time horizon. It is intended for scenario planning rather than definitive prognostication because, to date, there is no un

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Non-HDL-C to LDL Ratio Risk Index Calculator

Non-HDL-C to LDL-C Ratio: Explanation and Clinical Context The Non-HDL-C to LDL-C ratio represents the proportion of total atherogenic lipoproteins (all apoB-containing particles) relative to LDL cholesterol. While LDL-C has long been the cornerstone of lipid management, non-HDL-C provides a more comprehensive view of atherogenic burden, encompassing VLDL, IDL, and lipoprotein(a). Definition: Non-HDL-C is calculated

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PCOS Cardiometabolic Risk Index Calculator

PCOS Cardiometabolic Risk Index: Explanation and Clinical Context The PCOS Cardiometabolic Risk Index (PCRI) is a composite score designed to estimate the risk of metabolic and cardiovascular complications in women with Polycystic Ovary Syndrome (PCOS). It integrates age, BMI, waist circumference, fasting glucose, triglycerides, and HDL cholesterol into a single predictive metric. Higher scores indicate greater cardi

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Pheochromocytoma Perioperative Cardiac Risk Index (P-PCRI) Calculator

Pheochromocytoma Perioperative Cardiac Risk Index (P-PCRI): Explanation and Clinical Context This tool estimates the perioperative risk of significant intraoperative hemodynamic instability during adrenalectomy for pheochromocytoma by integrating preoperative clinical and CT-based predictors. Variables include age, BMI, tumor laterality, tumor shape, MAP score, necrosis, planned surgical technique, CHD status, and pr

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Postprandial Triglyceride Peak Risk Index Calculator

Postprandial Triglyceride Peak Risk Index: Explanation and Clinical Context Postprandial triglyceride (TG) elevation reflects the body’s ability to metabolize dietary fats after meals. Normally, plasma TG peaks within 3–4 hours postprandially and returns to baseline within 6–8 hours. A delayed TG peak, often observed in individuals with insulin resistance, obesity, or metabolic syndrome, is an early marker of endothe

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Primary Aldosteronism Cardiovascular Trait Score (PACT Score) Calculator

Primary Aldosteronism Cardiovascular Trait (PACT) Score: Explanation and Clinical Context The PACT Score is designed to quantify the cardiovascular risk in patients suspected of primary aldosteronism, integrating key clinical and biochemical traits such as blood pressure, serum potassium, plasma aldosterone concentration, and plasma renin activity. It calculates the Aldosterone-to-Renin Ratio (ARR) and assigns weight

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SGLT2 Benefit Probability Score Calculator

SGLT2 Benefit Probability Score: Explanation and Clinical Context The SGLT2 Benefit Probability Score is designed to estimate the likelihood of clinical benefit from SGLT2 inhibitors in patients with heart failure (HF), chronic kidney disease (CKD), and/or diabetes mellitus (DM). This tool incorporates key clinical variables such as age, presence of HF, CKD, and DM. Higher scores indicate a greater predicted benefit

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Thyroid Dysfunction Cardiovascular Risk Index (TSH Continuous Model)

: Explanation and Clinical Context The Thyroid Dysfunction Cardiovascular Risk Index is a predictive model designed to quantify cardiovascular risk associated with abnormal thyroid function using continuous TSH levels. It incorporates TSH levels, age, sex, systolic blood pressure, and total cholesterol to calculate a continuous risk index. Higher TSH levels, advanced age, male sex, elevated systolic blood pressure, a