Clinical library

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1,329 calculators and references across 60 specialties, with formula confidence shown up front.

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H2FPEF Score (Heart Failure with Preserved EF Probability) Calculator

H2FPEF Score: Explanation and Clinical Context The H2FPEF Score is a validated diagnostic scoring system designed to estimate the likelihood of heart failure with preserved ejection fraction (HFpEF) in patients presenting with unexplained dyspnea. It integrates six easily measurable clinical and echocardiographic variables: Heavy (BMI ≥30 kg/m²), Hypertensive (≥2 antihypertensive medications), Atrial fibrillation, Pu

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HAS-BLED Score Calculator

HAS-BLED Score: Explanation and Clinical Context HAS-BLED is a validated scoring system designed to assess the 1-year risk of major bleeding in patients with atrial fibrillation who are receiving anticoagulation therapy. It incorporates clinical risk factors including hypertension, abnormal renal or liver function, history of stroke or major bleeding, labile INR, age, concomitant use of drugs that increase bleeding r

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HATCH Score (AF Progression) Calculator

HATCH Score (Atrial Fibrillation Progression): Explanation and Clinical Context The HATCH Score is a validated risk assessment tool designed to predict the likelihood of progression from paroxysmal atrial fibrillation (AF) to persistent or permanent AF. Developed from a cohort study by De Vos et al., the score incorporates five key clinical predictors: heart failure, age >75 years, history of transient ischemic attac

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HbA1c Cardiac Event Prediction Calculator

HbA1c Cardiac Event Prediction Model: Explanation and Clinical Context The HbA1c Cardiac Event Prediction Model estimates the 5-year risk of cardiovascular events based on patient age, HbA1c level, and history of cardiovascular disease. Higher HbA1c reflects poorer glycemic control and is independently associated with elevated cardiovascular risk. Age contributes linearly to risk, while a history of cardiovascular di

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HCM Screening Yield (Community Athlete) Calculator

HCM Screening Yield Model (Community Athlete): Comprehensive Explanation and Clinical Context This calculator estimates the diagnostic yield of ECG-based pre-participation screening for hypertrophic cardiomyopathy (HCM) in community athletes. It combines sensitivity, specificity, and expected HCM prevalence to derive true positives, false negatives, false positives, and true negatives, as well as PPV, NPV, yield per

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Head Circumference Percentile Growth Chart Calculator

Age (months) Head Circumference (cm) Head Circumference Percentile Growth Chart Explanation and Clinical Context Head circumference percentile assessment is a tool used to evaluate head growth in infants and children as part of routine pediatric monitoring. Measurement reflects brain and skull development, giving clinicians insights into neurologic growth patterns. Interpretation typically refers to growth standards

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Heart Failure Polygenic Risk Score (HF-PRS) Calculator

Heart Failure Polygenic Risk Score (HF-PRS): Explanation and Clinical Context The Heart Failure Polygenic Risk Score (HF-PRS) quantifies an individual's genetic predisposition to heart failure by summing the weighted effects of multiple single nucleotide polymorphisms (SNPs) previously associated with the disease. It is calculated as the sum of the number of risk alleles for each SNP multiplied by its corresponding e

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Heart Rate Calculator from ECG Count

Heart Rate from ECG Count Calculation Explanation and Clinical Context Heart rate from ECG count is a simple bedside estimation derived from counting the number of R waves within a measurable ECG strip then converting it to beats per minute. It is highly useful during rapid assessments particularly when automated ECG interpretation is unavailable. The formula used is heart rate equals total R wave count divided by re

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Heart Rate Recovery (HRR) Calculator

Heart Rate Recovery Explanation and Clinical Context Heart rate recovery is the decline in heart rate that follows cessation of exercise. This physiological response reflects the reactivation of the parasympathetic nervous system and the gradual withdrawal of sympathetic drive. A slower reduction in heart rate after exercise indicates impaired autonomic function, which is a known predictor of cardiovascular morbidity

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Heart Rate Recovery (HRR) Index Postpartum Calculator

Heart Rate Recovery (HRR) Index Postpartum: Explanation and Clinical Context The Heart Rate Recovery (HRR) index postpartum is a measure of autonomic cardiovascular function following exercise in postpartum women. HRR is calculated as the difference between peak heart rate during exercise and heart rate measured one minute after cessation of exercise (HRR = HR_peak − HR_1min). A normal HRR at 1 minute postpartum is g

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Heart Rate Variability (HRV) Calculator

Heart Rate Variability (HRV): SDNN and RMSSD: Explanation and Clinical Context Heart Rate Variability (HRV) is a non-invasive marker of autonomic nervous system function and cardiac health. SDNN (Standard Deviation of NN intervals) represents overall HRV and reflects both sympathetic and parasympathetic influences. RMSSD (Root Mean Square of Successive Differences) reflects short-term parasympathetic activity and is

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HeartLogic Multisensor Algorithm (Approximate Calculator)

HeartLogic Multisensor Algorithm — Explanation, clinical context and references The HeartLogic algorithm is a proprietary, multisensor device diagnostic implemented in certain Boston Scientific implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy devices. It combines trends from multiple sensors — notably accelerometer-derived first and third heart sounds (S1, S3), intrathoracic (thora

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HeartQoL Global Index Calculator

HeartQoL Global Index: Explanation and Clinical Context The HeartQoL is a validated disease-specific health-related quality of life (HRQOL) questionnaire for patients with ischemic heart disease, including angina and myocardial infarction. It consists of a 14-item instrument with two subscales: Physical (10 items, range 0–32) and Emotional (4 items, range 0–24). The Global Index is calculated as the mean of Physical

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Heat Stress Cardiac Event Probability Model (Workplace)

: Explanation and Clinical Context This calculator estimates the relative short-term increase in cardiovascular event risk during a work shift in hot environments using WBGT. It anchors risk to a pragmatic WBGT threshold and scales risk by exceedance, shift duration, and vulnerability (age, known CVD, and medications that may impair heat tolerance). The temperature–risk elasticity is based on meta-analytic evidence t

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Heat-related Cardiac Strain Index (HRCSI) Calculator

Heat-related Cardiac Strain Index (HRCSI): Explanation and Clinical Context This calculator estimates cardiovascular strain due to heat by integrating environmental and workload factors into a 0–10 scale. Higher values indicate elevated cardiac stress and risk of heat-related symptoms or cardiovascular drift. The HRCSI combines an adjusted Heat Index (environmental burden) with metabolic workload (METs) and modifies

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Heavy Metal Exposure Cardiac Toxicity Index (Lead & Arsenic) Calculator

Heavy Metal Exposure Cardiac Toxicity Index (HM-CTI, Lead & Arsenic): Explanation and Clinical Context The HM-CTI is an evidence-informed, pragmatic index summarizing cardiovascular toxicity risk from two established environmental cardiotoxins: lead and inorganic arsenic. It uses two biomarkers—blood lead level (BLL, µg/dL) and urinary inorganic-related arsenic (iAs+MMA+DMA, µg/L)—to generate a 0–10 score, categorizi

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HELLP Cardiovascular Severity Index (CSI) Calculator

HELLP Cardiovascular Severity Index (CSI): Explanation and Clinical Context The HELLP Cardiovascular Severity Index (CSI) is a clinical tool used to assess the severity of cardiovascular involvement in patients with HELLP syndrome. It incorporates key laboratory markers—platelet count, AST (aspartate aminotransferase), LDH (lactate dehydrogenase)—and blood pressure levels to generate a total score. The CSI allows cli

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Hepatic Congestion Grading (Echo Doppler based) Calculator

Hepatic Congestion Grading (Echo Doppler based): Explanation and Clinical Context Hepatic congestion grading uses Doppler assessment of hepatic vein flow (S wave / D wave ratio) and inferior vena cava (IVC) diameter to quantify venous congestion. The S/D ratio reflects right atrial pressure and hepatic venous compliance, while IVC diameter indicates systemic venous overload. Grade 0 (no congestion) is indicated by no

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HER2 Therapy Cardiotoxicity Index (Trastuzumab) Calculator

HER2 Therapy Cardiotoxicity Index (Trastuzumab): Explanation and Clinical Context Trastuzumab, a monoclonal antibody targeting the HER2 receptor, is widely used in the treatment of HER2-positive breast cancer. However, its use is associated with an increased risk of cardiotoxicity, particularly in patients with pre-existing cardiovascular conditions, older age, prior anthracycline therapy, and elevated body mass inde

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HERDOO2 Score Calculator

HERDOO2 Score: Explanation and Clinical Context The HERDOO2 score is a clinical decision tool designed to identify women with unprovoked venous thromboembolism (VTE) who may safely discontinue anticoagulation after 5–12 months of therapy. It includes four variables: Hyperpigmentation, Edema, or Redness in either leg; D-dimer >250 μg/L; Obesity (BMI >30 kg/m²); and Older age >65 years. Each variable scores 1 point if

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Hestia Criteria (Outpatient PE Eligibility) Calculator

Hestia Criteria (Outpatient Pulmonary Embolism Treatment Eligibility): Explanation and Clinical Context The Hestia criteria provide a validated, simple tool to identify patients with acute pulmonary embolism who may be safely treated as outpatients. The criteria include hemodynamic stability, absence of active or high-risk bleeding, no need for supplemental oxygen to maintain saturation above 90%, no severe comorbidi

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HF-CARB (Chronic Ambulatory HF Risk Model) Calculator

HF-CARB (Chronic Ambulatory Heart Failure Risk Model) — explanation and clinical context This 5-item clinical model (derived from IC-BERG recommendations) evaluates ambulatory patients with chronic heart failure at the clinic by checking five simple features: NYHA class III–IV, clinical signs of congestion, a hospitalization or emergency visit for HF in the previous 12 months, a daily loop diuretic dose ≥40 mg furose

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HF-CRT Echo Resynchronization Index Calculator

HF-CRT Echo Resynchronization Index: Explanation and Clinical Context The HF-CRT Echo Resynchronization Index is a composite echocardiographic measure designed to quantify the mechanical dyssynchrony and remodeling response in patients undergoing cardiac resynchronization therapy (CRT). It integrates key mechanical and electrical parameters that have been shown to predict CRT benefit, including septal-to-lateral dela

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HF-CRT Echo Resynchronization Index Calculator

HF-CRT Echo Resynchronization Index: Explanation and Clinical Context The HF-CRT Echo Resynchronization Index is a composite echocardiographic measure designed to quantify the mechanical dyssynchrony and remodeling response in patients undergoing cardiac resynchronization therapy (CRT). It integrates key mechanical and electrical parameters that have been shown to predict CRT benefit, including septal-to-lateral dela

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HFA-ICOS Cardio-Oncology Risk Score Calculator

HFA-ICOS Cardio-Oncology Risk Score (ESC 2022): Explanation and Clinical Context The HFA-ICOS Cardio-Oncology Risk Score is designed to stratify patients based on their baseline cardiovascular risk when initiating potentially cardiotoxic cancer therapy. The score incorporates patient-specific factors including age, sex, hypertension, diabetes, prior heart failure or cardiomyopathy, previous cardiovascular disease, an

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HFA-ICOS Dynamic Surveillance Index Calculator

HFA-ICOS Dynamic Surveillance Index: Explanation and Clinical Context The HFA-ICOS Dynamic Surveillance Index is a risk stratification tool developed by the Heart Failure Association of the European Society of Cardiology and the International Cardio-Oncology Society. It is designed to assess the cardiovascular risk in oncology patients prior to initiating potentially cardiotoxic anti-cancer therapies. The index consi

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HFA-PEFF Score Calculator

HFA-PEFF Score: Explanation and Clinical Context The HFA-PEFF algorithm is a stepwise diagnostic approach for suspected heart failure with preserved ejection fraction (HFpEF) that uses three domains — functional (diastolic function / filling pressure and longitudinal strain), morphological (left atrial enlargement, left ventricular hypertrophy/geometry), and biomarkers (natriuretic peptides). Each domain contributes

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High Bleeding Risk (HBR) Diagnosis Score Tool

High Bleeding Risk Diagnosis Score Tool Explanation and Clinical Context This calculator summarizes major bleeding related factors highlighted in the twenty twenty five American Heart Association acute coronary syndrome guideline to assist clinicians in identifying patients who have elevated bleeding potential during antithrombotic therapy. The variables reflect clinical domains frequently associated with hemorrhagic

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High Sensitivity Troponin 0/1 Hour Rule Out Rule In Algorithm Tool

References Rao SV et al Twenty twenty five Acute Coronary Syndromes Guideline J Am Coll Cardiol Twenty twenty five Reichlin T et al One hour rule out and rule in of myocardial infarction using high sensitivity troponin T Arch Intern Med Twenty twelve Twerenbold R et al Prospective validation of the zero one hour algorithm J Am Coll Cardiol Twenty eighteen Chiang CH et al Safety of the ESC zero one hour algorithm Hear

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High-G Cardiac Screening Index (Aviation) Calculator

High-G Cardiac Screening Index (Aviation): Explanation and Clinical Context What this calculator does. It implements the Cardiac Force Index (CFI) framework reported in military aircrew: CFI = body weight × activity ÷ heart rate. Using wearable-derived activity at rest and during comfortable walking, the tool outputs RCFI (rest), WCFI (walk), and the Cardiac Force Ratio (CFR = WCFI/RCFI) that summarizes reserve from

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HIV-Associated Cardiomyopathy Risk Score Calculator

HIV-Associated Cardiomyopathy Risk Score: Explanation and Clinical Context HIV-associated cardiomyopathy (HIV-CM) represents a spectrum of myocardial dysfunction in individuals living with HIV, driven by multifactorial mechanisms such as chronic immune activation, direct viral injury, ART toxicity, and comorbid cardiovascular risk factors. The proposed scoring model estimates the probability of subclinical or overt c

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HLHS Norwood Survival Predictor Calculator

HLHS Norwood Survival Predictor: Explanation and Clinical Context The HLHS Norwood Survival Predictor estimates the probability of survival following the Norwood procedure in neonates with Hypoplastic Left Heart Syndrome (HLHS). It uses key preoperative clinical variables, including birth weight, gestational age, need for preoperative mechanical ventilation, and presence of coronary artery anomalies. Lower birth weig

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HOMA-IR (Insulin Resistance Index) Calculator

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance): Explanation and Clinical Context HOMA-IR is a validated index used to estimate insulin resistance based on fasting plasma glucose and insulin levels. The formula is: HOMA-IR = (Fasting Glucose [mg/dL] × Fasting Insulin [µU/mL]) / 405. Higher HOMA-IR values indicate greater insulin resistance. It is commonly used in metabolic and cardiometabolic research an

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Hospital Anxiety and Depression Scale (HADS) Calculator

Hospital Anxiety and Depression Scale (HADS): Explanation and Clinical Context The Hospital Anxiety and Depression Scale (HADS) is a validated self-assessment questionnaire designed to detect states of anxiety and depression in patients in hospital and outpatient settings. It consists of 14 items, 7 assessing anxiety (HADS-A) and 7 assessing depression (HADS-D), with each item scored from 0 to 3, resulting in a total

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HOST-EXAM Bleeding vs Ischemic Risk Index

How this tool works — clinical & methodological notes This page computes the DAPT score exactly as published by Yeh et al. (points assigned per original paper) to estimate ischemic vs bleeding trade-offs for continuing dual antiplatelet therapy after 12 months. The DAPT score ranges roughly from −2 to +10; a score ≥2 suggests potential ischemic benefit from prolonged DAPT (but this must be balanced with bleeding risk

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HPEL (Hyperlipidemia) Predicted ASCVD Increment Calculator

Current LDL-C (mg/dL) Reference/Target LDL-C (mg/dL) (e.g., 70) HPEL (Hyperlipidemia) Predicted ASCVD Increment: Explanation and Clinical Context This tool estimates the incremental atherosclerotic cardiovascular disease (ASCVD) risk attributable to elevated LDL-C relative to a user-defined reference (commonly 70 mg/dL) by applying a log-linear relationship between LDL-C and major vascular events derived from large,

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hs-CRP Tertile Risk Category Calculator

hs-CRP Tertile Risk Category: Explanation and Clinical Context The hs-CRP (high-sensitivity C-reactive protein) tertile risk categorization stratifies patients into low, intermediate, or high risk of future cardiovascular events based on their hs-CRP levels. According to Ridker et al. (Circulation, 2000), the 1st tertile (<1.0 mg/L) represents low risk, the 2nd tertile (1.0–3.0 mg/L) represents intermediate risk, and

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Hs-CRP Tertile Stratification Calculator

Hs-CRP Tertile Stratification: Explanation and Clinical Context High-sensitivity C-reactive protein (Hs-CRP) is a biomarker of systemic inflammation widely used in cardiovascular risk assessment. Tertile stratification categorizes individuals into three risk groups based on circulating Hs-CRP concentrations: Tertile 1 (<1.0 mg/L) indicates low cardiovascular risk, Tertile 2 (1.0–3.0 mg/L) indicates intermediate risk,

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hs-Troponin Delta Algorithm (0 to1-h and 0 to 2-h ESC models) Calculator

hs-Troponin Delta Algorithm (0/1-h and 0/2-h ESC models): Explanation and Clinical Context The high-sensitivity troponin (hs-Tn) delta algorithms are validated tools to rapidly triage patients presenting with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS). The 0/1-hour algorithm uses the baseline hs-Tn level and the absolute change after 1 hour to stratify patients into 'Rule-Out', 'Rule-In', or 'Obser

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HScore for Hemophagocytic Lymphohistiocytosis Calculator

HScore for Hemophagocytic Lymphohistiocytosis Explanation and Clinical Context HScore is a validated clinical tool developed to estimate the probability of reactive Hemophagocytic Lymphohistiocytosis also known as secondary HLH. It integrates clinical findings laboratory abnormalities and bone marrow evaluation to produce a weighted score that correlates with the likelihood of HLH. The variables include the degree of

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Hypertension Screening ROI Model (Health System) Calculator

Hypertension Screening ROI Model (Health System): Explanation and Clinical/Economic Context This calculator estimates the financial return from implementing a systematic hypertension screening pathway across a health system. It follows a standard budget-impact/ROI framing: total discounted cost savings from major cardiovascular (CVD) events averted minus the total discounted costs of screening, confirmatory assessmen

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Hypertensive Heart Disease Severity Scale (HHDS) Calculator

Hypertensive Heart Disease Severity Scale (HHDS): Explanation and Clinical Context HHDS is a validated tool to assess the severity of cardiac involvement in patients with chronic hypertension. It evaluates structural and functional parameters of the heart including left ventricular hypertrophy (LVH), left atrial enlargement (LAE), diastolic dysfunction, and systolic dysfunction (EF <50%). The cumulative score stratif

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Hypertensive-Mediated Organ Damage (HMOD) Index Calculator

Hypertensive-Mediated Organ Damage (HMOD) Index: Explanation and Clinical Context HMOD Index is a validated tool to quantify the cumulative impact of hypertension on target organs including the heart, kidneys, arteries, and retina. It considers the presence of left ventricular hypertrophy (LVH), renal impairment (eGFR <60 mL/min/1.73m² or albuminuria), arterial stiffness (e.g., carotid intima-media thickness >0.9mm),

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Hypertriglyceridemic Waist (HTGW) Index Calculator

Hypertriglyceridemic Waist (HTGW) Index: Explanation and Clinical Context The HTGW Index is a simple clinical tool combining waist circumference and fasting triglyceride levels to identify individuals at increased cardiometabolic risk. It was first described by Lemieux et al. in 2007 as a marker for visceral obesity and associated metabolic abnormalities, such as insulin resistance, atherogenic dyslipidemia, and incr